【Abstract】Objective: To research the clinical feasibility of emergency right lobe adult-to-adult live-donor liver transplantation for high MELD score severe hepatitis. Method: Consecutive ten high MELD score severe hepatitis patients(4 acute-on-chronic severe hepatitis and 6 acute severe hepatitis)(9 caused by HBV and 1 with drug-induced acute liver failure) underwent emergency right lobe adult-to-adult live-donor liver transplantation in our hospital from Apr 2007 to Dec 2007. The Mean±SD of Model for End-Stage Liver Disease (MELD)(mean±sd) score was 33.22±6.55. The outcomes of these recipients were perspectively analyzed. Results:Among them,8 ABO blood group were identical and 2 compartible. One was Rh sub-group negtive.Except 2 recipients died(1 acute renal failure by veno cava thrombosis,1 liver failure by hepatic artery thrombosis), the rest of recipients(80% ) and all donor are safe. The mean graft-to-recipient weight ratio (GRWR) (mean±sd) was 1.19±0.14% , and graft volume to recipient estimated standard liver volume ratio(GW/ESLV) (mean±sd)was 65.13±8.75% .Right lobe grafts with middle hepatic vein(MHV) 3 cases, without MHV 4 cases, without MHV but followed by Ⅴand Ⅷ hepatic vein outflow reconstruction 3 cases.Encouraging outcome was achieved in this group of recipient:elevated serum creatinine,serum endotoxin,total bilirubin and decreased serum prothrombin activity(PTA) returned to normal about on postoperative day (POD) 3, POD 7, POD 14 and POD 28,respectively. Conclusions: Outcomes of emergency right lobe adult-to-adult live-donor liver transplantation for high MELD score severe hepatitis are fairly encouraging and acceptable. emergency right lobe adult-to-adult live-donor liver transplantation is an effective and life-saving modality for high MELD score acute liver failure.as well